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PDGF-DD Protein Human (CHO) is a member of the PDGF family specifically binds to and activates its cognate receptor PDGFR- and participates in regulating cancer proliferation transformation and invasion through activating multiple downstream oncogenic pathways resulting in tumor development and progression
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Platelet-derived growth factor is commonly known as a mitogen Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells There are four members of PDGF family known as PDGF-A chain PDGF-B chain PDGF-C chain and PDGF-D chain which in active forms are dimers As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF
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